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99% White Crystalline Estrogen Solid Mestranol CAS NO 72-33-3 Used to Prevent Pregnancy

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99% White Crystalline Estrogen Solid Mestranol CAS NO 72-33-3 Used to Prevent Pregnancy

China 99% White Crystalline Estrogen Solid Mestranol CAS NO 72-33-3 Used to Prevent Pregnancy supplier
99% White Crystalline Estrogen Solid Mestranol CAS NO 72-33-3 Used to Prevent Pregnancy supplier 99% White Crystalline Estrogen Solid Mestranol CAS NO 72-33-3 Used to Prevent Pregnancy supplier 99% White Crystalline Estrogen Solid Mestranol CAS NO 72-33-3 Used to Prevent Pregnancy supplier 99% White Crystalline Estrogen Solid Mestranol CAS NO 72-33-3 Used to Prevent Pregnancy supplier 99% White Crystalline Estrogen Solid Mestranol CAS NO 72-33-3 Used to Prevent Pregnancy supplier

Large Image :  99% White Crystalline Estrogen Solid Mestranol CAS NO 72-33-3 Used to Prevent Pregnancy

Product Details:

Place of Origin: China
Brand Name: ND
Certification: GMP
Model Number: CAS NO:72-33-3

Payment & Shipping Terms:

Minimum Order Quantity: 5 grams
Price: Negotiation
Delivery Time: Within 3 work days
Payment Terms: T/T, Western Union, MoneyGram,Bitcoin,PayPal
Supply Ability: 1000 kg/Year
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Detailed Product Description
CAS NO: 72-33-3 Assay: 99%
Appearance: White Crystalline Powders Product Name: Mestranol
MF: C21H26O2 Usage: For Prevent Pregnancy

 99% White Crystalline Estrogen Solid Mestranol CAS NO:72-33-3 Used to Prevent Pregnancy ,Cutting Steroids

 

Anabolic steroid Mestranol 72-33-3
Synonyms: Mestranol powder; Inostral; Mestranol
CAS: 72-33-3
Formula: C21H26O2
Molecular Weight: 310.47
EINECS: 200-777-8
Melting Point: 153-155 ° C(lit. )
Appearance: Crystalline solid
Purity: >99%
PackAge: Aluminium foil bag packing
Storage: Keep in cool and dry place, away from light.


99% White Crystalline Estrogen Solid Mestranol CAS NO 72-33-3 Used to Prevent Pregnancy


Quick Detail:
 

Product name Mestranol
Other name 2-Methyl-4-trimethylsilyl-3-butyn-2-ol
CAS No 72-33-3
MF C8H16OSi
MW 156.2975
Purity 98%
Appearance white crystalline solid

Description:

Mestranol is the 3-methyl ether of ethinylestradiol. It was the estrogen used in many of the first oral contraceptives.
It is a biologically inactive prodrug of ethinylestradiol to which it is demethylated in the liver with a conversion efficiency of 70% (50 µg of mestranol is pharmacokinetically bioequivalent to 35 µg of ethinylestradiol).
Mestranol is the 3-methyl ether of ethinylestradiol. Ethinylestradiol, is a synthetic derivative of estradiol. Ethinylestradiol is orally bio-active and the estrogen used in almost all modern formulations of combined oral contraceptive pills. It binds to (and activates) the estrogen receptor. Mestranol is a biologically inactive prodrug of ethinylestradiol to which it is demethylated in the liver with a conversion efficiency of 70%. Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).

History:

In April 1956, noretynodrel was investigated, in Puerto Rico, in the first large-scale clinical trial of aprogestogen as an oral contraceptive. The trial was conducted in Puerto Rico due to the high birth rate in the country and concerns of moral censure in the United States. It was discovered early into the study that the initial chemical syntheses of noretynodrel had been contaminated with small amounts (1-2%) of the 3-methyl ether of ethinylestradiol (noretynodrel having been synthesized from ethinylestradiol). When this impurity was removed, higher rates of breakthrough bleedingoccurred. As a result, mestranol, that same year (1956), was developed and serendipitously identified as a very potent synthetic estrogen (and eventually as a prodrug of ethinylestradiol), given its name, and added back to the formulation. This resulted in Enovid by G. D. Searle & Company, the first oral contraceptive and a combination of 9.85 mg noretynodrel and 150 μg mestranol per pill.

Around 1969, mestranol was replaced by ethinylestradiol in most or all combined oral contraceptives due to widespread panic about the recently uncovered increased risk of venous thromboembolism with estrogen-containing oral contraceptives. The rationale was that ethinylestradiol was approximately twice as potent by weight as mestranol and hence that the dose could be halved, which it was thought might result in a lower incidence of venous thromboembolism.Whether this actually did result in a lower incidence of venous thromboembolism has never been assessed.

Applications:

This combination hormone medication is used to prevent pregnancy. It contains 2 hormones: a progestin and an estrogen. It works mainly by preventing the release of an egg (ovulation) during your menstrual cycle. It also makes vaginal fluid thicker to help prevent sperm from reaching an egg (fertilization) and changes the lining of the uterus (womb) to prevent attachment of a fertilized egg. If a fertilized egg does not attach to the uterus, it passes out of the body.
Besides preventing pregnancy, birth control pills may make your periods more regular, decrease blood loss and painful periods, decrease your risk of ovarian cysts, and also treat acne.
Using this medication does not protect you or your partner against sexually transmitted diseases

 

 

 

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