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Product Name: | Tamoxifen Citrate | Other Name: | Nolvadex |
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CAS: | 54965-24-1 | Appearance: | White Powder |
MF: | C32H37NO8 | Assay: | 99.5% |
MW: | 563.64 | MP: | 140-144 ºC |
EINECS: | 259-415-2 | WhatsApp: | +86 17683962426 |
High Light: | bodybuilding estrogen blocker,breast cancer steroids |
CAS:54965-24-1
MF:C32H37NO8
MW:563.64
EINECS:259-415-2
Synonyms:1-p-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene citrate;(z)-2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethanamine,citrate(1: ;(z)-2-(para-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethylaminecitrate( ;2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethyl-ethanamin(z)-ethanamin2-hydrox ;ici46,474 ;kessar ;noltam ;tamofen
Melting point:140-144 °C
storage temp. 2-8°C
solubility methanol: soluble50mg/mL, clear, colorless
form Powder
color White to off-white
Water Solubility slightly soluble
Sensitive Light Sensitive & Hygroscopic
Merck 14,9048
Symbol(GHS)
Description
Nolvadex (tamoxifen citrate) is very comparable to Clomid, behaves in the same manner in all tissues, and is a mixed estrogen agonist/antagonist of the same type as Clomid. The two molecules are also very similar in structure. It is not correct that Nolvadex reduces levels of estrogen: Rather, it blocks estrogen from estrogen receptors and, in those tissues where it is an antagonist, causes the receptor to do nothing.
The claim that Nolvadex reduces gains should not be taken too seriously. The fact is that any number of bodybuilders have made excellent gains while using Nolvadex.
The belief that it reduces gains seems to stem from the fact that the scientific literature reports a slight reduction (individuals using anabolic steroids were not studied though) from use of Nolvadex.
However, while being an antagonist it is also an agonist as it will actually act as estrogen in certain parts of the body while acting as an anti-estrogen in other areas. As one of the oldest SERM's on the market that is still regularly used medicinally, while Nolvadex is also used by anabolic steroid users it is not an anabolic steroid. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it.
Because of this competitive antagonism, tamoxifen acts like a key broken off in the lock that prevents any other key from being inserted, preventing estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.Tamoxifen was discovered by pharmaceutical company Imperial Chemical Industries(now AstraZeneca) and is sold under the trade names Nolvadex,Istubal, and Valodex. However, the drug has been widely referred to by its generic name "tamoxifen", even before its patent expiration.
Specification
Test Items | Specification | Test Results |
Description | White crystalline powder | White crystalline powder |
Identification | IR , UV conform | Conform |
Loss on drying | ≤0.5ml | 0.21ml |
Residue on ignition | Not more than 0.2% | 0.06ml |
Iron | Not more than 0.005% | 0.00% |
Heavy metals | Not more than 0.001% | 0.00% |
Related substances | Total: Not more than 1.0% | 0.32% |
Individual: Not more than 0.5% | 0.14% | |
E-isomer | Not more than 0.3% | 0.19% |
Organic volatile impurities | Conforms | Conforms |
Assay | 99.0~101.0% | 99.51% |
Conclusion | Conform with USP30 |
Functions
While Nolvadex is effective against estrogen, it is not our strongest available remedy. Nolvadex is an estrogen agonist in the liver, capable of activating the estrogen receptor and mimicking the actions of this sex hormone in this region of the body. As such it can have a markedly positive impact on HDL (good) cholesterol values, as does estrogen. While primarily viewed as an anti-estrogen, Nolvadex also has the ability to act as estrogen, specifically in the liver. This presents a benefit as estrogenic activity in the liver has been linked to healthier cholesterol levels. For the steroid user, this can be extremely beneficial as many anabolic steroids tend to have an adverse effect on cholesterol.
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