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Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For Anti Estrogen

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Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For Anti Estrogen

China Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For Anti Estrogen supplier
Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For Anti Estrogen supplier Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For Anti Estrogen supplier Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For Anti Estrogen supplier Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For Anti Estrogen supplier

Large Image :  Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For Anti Estrogen

Product Details:

Place of Origin: CN
Brand Name: Raloxifene Hydrochloride
Certification: GMP , ISO 9001
Model Number: 82640-04-8

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Contact Me
Packaging Details: Aluminum Foil Bag/Hide the packaging
Delivery Time: Within 24 hours
Payment Terms: Western Union Paypal BTB Money Gram T/T
Supply Ability: 1000kg/Month
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Detailed Product Description
Product Name: Raloxifene Hydrochloride Other Name: Raloxifene ; Raloxifene HCL
CAS: 107868-30-4 Appearance: White Crystalline Powder
MF: C20H24O2 Assay: 99%
MW: 510.04 MP: 250-253°C

 

Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For Anti Estrogen

 

 

Raloxifene Hydrochloride

Pharmaceutical Raw Material White Powder Raloxifene Hydrochloride / Raloxifene HCl CAS 82640-04-8 For  Anti Estrogen
 

CAS:82640-04-8

MF:C28H28ClNO4S

MW:510.04

Synonyms:RALOXIFENE HCL;RALOXIFENE HYDROCHLORIDE;ly156758 ;methanone,(6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidin ;KEOXIFENE;KEOXIFENE HYDROCHLORIDE;LY 139481;AKOS 92138

 
 

Properties

 

Melting point:250-253°C

storage temp. -20°C Freezer

solubility DMSO: 28 mg/mL, soluble

 

 

Abstract

 

Raloxifene hydrochloride is a second-generation Selective Estrogen Receptor Modulator (SERM) of the benzothiophene family. This drug is similar in effect to tamoxifen, exhibiting estrogen receptor antagonist (blocking) properties in some tissues while acting as an estrogen receptor agonist (activator) in others.

The main point of variation between these two agents is their tissue selectivity. While raloxifene hydrochloride is a strong anti-estrogen in breast and uterine tissues, it appears to be estrogenic in bone. This allows it to protect bone density, mimicking the beneficial effects of endogenous estradiol. This is quite different from tamoxifen, which is anti-estrogenic in both breast and bone.

In a role that was novel for an anti-estrogen, raloxifene hydrochloride was approved by the FDA for the prevention and treatment of osteoporosis in post-menopausal women. It is also being investigated for several other potential uses, including the treatment and prevention of cardiovascular disease, breast cancer, gynecomastia, prostate cancer, acromegaly, and uterine cancer.


Raloxifene Hydrochloride is used to help prevent and treat thinning of the bones (osteoporosis) only in postmenopausal women.

It works like an estrogen to stop the bone loss that can develop in women after menopause, but it does not increase the bone density as much as daily 0.625 mg doses of conjugated estrogens. Raloxifene Hydrochloride will not treat hot flashes of menopause and may cause hot flashes to occur. Also, Raloxifene Hydrochloride does not stimulate the breast or uterus as estrogen does.

Raloxifene Hydrochloride lowers the blood concentrations of total and low-density lipoprotein (LDL) cholesterol, the bad cholesterols, but it does not increase concentrations of high-density lipoprotein (HDL) cholesterol, the good cholesterol, in your blood.

Raloxifene Hydrochloride is also used to lower chances of having invasive breast cancer in postmenopausal women with osteoporosis or at high risk of having invasive breast cancer .
This medicine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Raloxifene Hydrochloride is used in certain patients with the following medical conditions:

Breast cancer prevention in high-risk women who have already gone through menopause.


Application


May prevent or treat corticosteroid-induced bone loss. American College of Rheumatology states that raloxifene can be offered to selected postmenopausal corticosteroid-treated women who refuse hormone replacement therapy or other antiresorptive agents or in whom such therapies are contraindicated.


Reduction in the incidence of invasive breast cancer inpostmenopausal women at high risk for developing the disease. Effect comparable to that of tamoxifen in reducing the risk of invasive breast cancer (STAR trial). No effect on the risk of lobular carcinoma in situ or ductal carcinoma in situ (STAR trial).


Effect on breast cancer incidence in women with BRCA1 or BRCA2 genetic mutations not established. Not indicated for the treatment of breast cancer or to reduce the risk of recurrence of breast cancer. 1 Not indicated for reduction in the risk of noninvasive breast cancer.

 

 

Usage


1. Amino acid, nutrient


2. Labeled , intended for use as an internal standard for the quantification by GC- or LC-mass
spectrometry.


3. A nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.

 

Mechanism of Action


Evista (raloxifene hydrochloride) is an estrogen agonist/antagonist, referred to as a selective estrogen receptor modulator (SERM) and belongs to the benzothiophene class of compounds. The biological actions of raloxifene are largely mediated through binding to estrogen receptors.

This binding results in activation of estrogenic pathways in some tissues (agonism) and and the blockade of estrogenic pathways in other tissues (antagonism). The agonistic or antagonistic activity of raloxiffene depends on the extent of recruitment of coactivators and corepressors to estrogen receptor (ER) target gene promotors.

 

 

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1: After our quation ,you will choose to accept or not.
2: If you decide to have a try, choose a payment method to pay for the order.
3: We will sent the package out in 24hours after we received the payment ,then will sent the tracking number with packaging detail to you via mai.
4: We will help track the package until you receive it successful,if accident happen ,we will see the reason to decide re-sent for free or half-price re-sent.


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