Growth Hormone Peptides Nesiritide Acetate (Bnp-32) For Antimicrobial CAS 114471-18-0

Basic info:

Nesiritide Acetate (BNP-32)
Synonyms:Natriureticpeptide,brain;Brain natriuretic peptide, human;Brain natriuretic peptide (1-32), human;Brain natriuretic peptide-32;Brain natriuretic peptide-32 (human);Brain(b-type) natriuretic peptide-32 (human);B-type (brain) natriuretic peptide-32 (human);Bnp human
Cas No. 114471-18-0
Molecular Formula C143H244N50O42 S4
Molecular Weight 3464.04
Purity (HPLC) 98.0%min.
Appearance White powder
Single Impurity(HPLC) 1.0%max
Amino Acid Composition ±10% of theoretical
Peptide Content(N%) ≥78.0%
Water Content(Karl Fischer) ≤6.0%
Acetate Content(HPIC) ≤15.0%
MS(ESI) Consistent
Mass Balance 95.0~105.0%
Usage: Hemostatic, Antimicrobial

Description

Nesiritide (Natrecor) is the recombinant form of the 32 amino acid human B-type natriuretic peptide, which is normally produced by the ventricular myocardium. Nesiritide works to facilitate cardiovascular fluid homeostasis through counterregulation of the renin-angiotensin-aldoesterone system, stimulating cyclic guanosine monophosphate, leading to smooth muscle cell relaxation.

Neseritide was believed initially to be beneficial for acute decompensated congestive heart failure. It received approval from the United States' Food and Drug Administration for this purpose in 2001 after initial non-approval. In July 2011 the results of the largest study so far for nesiritide was published in The New England Journal of Medicine; it showed that nesiritide was not associated with a change in mortality or re-hospitalizations.

In 2005, after several academic papers published by Jonathan Sackner-Bernstein on the efficacy and side effects of Nesiritide, Johnson & Johnson met with the FDA and altered its stated plans for the drug and agreed to revise its labeling.

Heart doctors at the Cleveland Clinic then voted unanimously not to permit the prescription of the drug to its patients.Following this, the United States Department of Justice announced an inquiry into the marketing of the drug.

Nesiritide of synthetic recombinant human B -type natriuretic peptide (recombined human B-type natriuretic peptide, rhBNP), and ventricular natural natriuretic peptide secretion sodium has the same 32 amino acid sequence . Nesiritide with guanylyl vascular smooth muscle and endothelial cells cyclase receptors, increase intracellular cGMP content , cGMP as a second messenger to make arteriovenous expansion. Studies have shown that nesiritide make endothelin or α- adrenergic receptor agonist treatment of isolated human artery and vein dilation . In the human body, nesiritide dose- dependent reduction in heart failure patients with pulmonary capillary wedge wedge pressure (pulmonary capillarywedge pressure, PCWP) and arterial pressure.

Applications:

Mainly has a strong angiotensin II vasoconstriction and increase in blood pressure. The mechanism is: 1. So that the body arteriole smooth muscle contraction, increased peripheral resistance; 2. So increase the release of adrenal aldosterone, causing sodium retention, increased blood volume; 3. Directly contribute to renal tubular sodium and water reabsorption; 4. So the brain central nervous sympathetic vasoconstrictor activity, causing increased peripheral vascular resistance; 5. Stimulate the adrenal medulla to release epinephrine and norepinephrine

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