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|Appearance:||White Crystalline Powders||Product Name:||Anastrozole / Arimidex|
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99% antibiotic powder Anastrozole / Arimidex / CAS No.:120511-73-1
Anastro Zole Product Name: Anastro Zole,Arimidex
Anastro Zole Alias: Armotraz,Anastrol,Egistrozol,Anastro Zole
Anastro Zole CAS NO. : 120511-73-1
Anastro Zole Assay : 98%~102%
Anastro Zole Appearance : White crystalline powder
Anastro Zole Active life cycle : 46 hours
Anastro Zole MF: C17H19N5
Anastro Zole MW: 293.37
What is Anastro Zoles / Arimidex?
RIMIDEX (Anastro Zole) is a non-steroidal aromatase inhibitor. It is chemically described as 1,3-Benzenediacetonitrile, a, a, a', a'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl). Its molecular formula is C17H19N5.
Anastro Zole is an off-white powder with a molecular weight of 293.4. Anastro Zole has moderate aqueous solubility (0.5 mg/mL at 25°C); solubility is independent of pH in the physiological range. Anastro Zole is freely soluble in methanol, acetone, ethanol, and tetrahydrofuran, and very soluble in acetonitrile.
Anastro Zole is an aromatase inhibitor, an anti-cancer medication use for the adjuvant or initial treatment of breast cancer in post-menopausal women. Estrogen causes or increases growth of certain breast cancers. Anastro Zole works by blocking aromatase enzyme, which is involved in estrogen production in the body. This leads to decreased tumor size or delayed progression of tumor growth in some women. The FDA approved brand name anastro Zole (Arimidex) in 1995.
Anastro Zole is prescribed for hormone receptor-positive, early breast cancer in postmenopausal women as adjuvant treatment ( treatment following surgery with or without radiation ). Anastro Zole is prescribed as a first-line treatment for hormone receptor-positive or hormone receptor unknown, locally advanced or metastatic breast cancer in postmenopausal women. Anastro Zole is also prescribed for the treatment of advanced breast cancer in postmenopausal women with disease progression following treatment with tamoxifen (Nolvadex, Soltamox).
Anastro Zoles / Arimidex Usage:
Anastro Zole is a powerful Aromatase Inhibitor (AI)under the brand name Arimidex for the purpose of fighting breast cancer. Since its inception,Anastro Zole has been one of the leading anti-estrogenic medications on the market. The compound has proven far more effective in breast cancer treatment plans than Tamoxifen Citrate (Nolvadex), although both compounds are regularly used.
Anastro Zole has also gained a lot of attention in recent years due to its use in testosterone replacement therapy (TRT) plans. Many TRT patients find the use of exogenous testosterone increases their estrogen levels, but by including Anastro Zole in the program estrogen can be controlled. For any TRT plan to be successful, estrogen along with testoster one must be balanced and Anastro Zole can help the patient reach this end.
Many anabolic steroid users supplement with Anastro Zole during what is known as the Post Cycle
Therapy (PCT) phase following a steroid cycle. The PCT phase is implemented in order to stimulate natural testoster one production that has been suppressed due to anabolic steroid use. While Anastro Zole can stimulate natural testoster one production, it is not a suitable medication for PCT. Stimulating natural testoster one production is the primary purpose of PCT but beyond stimulation is promoting normalization,which cannot be accomplished by dramatically suppressing estrogen levels, which will occur with the amount of Anastro Zoleneeded to fully stimulate testoster one production.
For the breast cancer patient, standard Anastro Zole doses will normally be 1mg every day until the cancer subsides. This is a very large dose but necessary in such therapeutic plans. For the TRT patient,standard Anastro Zole doses will normally fall in the 0.5mg two times per week range. This is normally enough to control estrogen when supplementing with therapeutic testoster one doses. Steroid users supplementing with supraphysiological doses of testoster one often need 0.25-0.5mg every other day inorder to combat the large amounts of aromatase activity.
Anastro Zoles / Arimidex Dosages:
The drug is appropriately used when using substantial amounts of aromatizing steroids, or when one is prone to gynecomastia and using moderate amounts of such steroids. Arimidex does not have the side effects of aminoglutethimide (Cytadren) and can achieve a high degree of estrogen blockade, much moreso than Cytadren. It is possible to reduce estrogen too much with Arimidex, and for this reason blood tests, or less preferably salivary tests, should be taken after the first week of use to determine if the dosing is correct.
Anastro Zoles / Arimidex COA:
|Description||White crystalline powder||Complies|
|Conform with standard IR
Conform with standard HPLC
|Solubility||Freely soluble in methanol,acetone,ethanol and tetrahydrofuran.And very soluble in acetonitrile||Complies|
|Total Unspecified Impurity||max. 0.2%||0.08%|
|Individual unspecified impurlty||max. 0.1%||0.05%|
|Related compound B||max. 0.2%||0.07%|
|Related compound C||max. 0.2%||0.04%|
|Related compound D||max. 0.1%||0.05%|
|Related compound E||max. 0.1%||0.06%|
|Limit of ethylacetate||max. 0.1%||0.07%|
|Residue on ignition||max. 0.1%||0.07%|
|Storage||Cool and dry|
|Conclusion||It complies to USP32 .|
Anastrozole has been tested for reducing estrogens, including estradiol, in men. Excess estradiol in men can cause benign prostatic hyperplasia, gynecomastia, and symptoms of hypogonadism. It can also contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargement and prostate cancer. Some athletes and body builders use anastrozole as part of their steroid cycle to reduce and prevent symptoms of excess estrogen--gynecomastia, emotional lability and water retention. Study data suggest dosages of 0.5 mg to 1 mg a day reduce serum estradiol by approximately 50% in men, which differs in postmenopausal women.
Anastrozole may be used off-label in children with precocious puberty, or children with pubertal gynecomastia. Following the onset of puberty, the epiphyseal plate begins to close due to an increased amount of estrogen production escaping local metabolism and spreading to the circulatory system. It is shown to help slow this process, and increase adult height prediction in adolescent males treated with protein-based peptide hormones for the treatment of growth hormone deficiency.
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