Doublewin Biological Technology Co., Ltd.
             Quality Product 丨 Safe Delivery 丨 Professional Service

Home
Products
About Us
Factory Tour
Quality Control
Contact Us
Request A Quote
Company News
Home ProductsRaw Steroid Powders

Top Quality Powder Nsi-189 CAS 1270138-40-3 for Memory Enhancement and Depressive Disorder Treatment

I'm Online Chat Now
Certification
China Doublewin Biological Technology Co., Ltd. certification
China Doublewin Biological Technology Co., Ltd. certification
Glad to do business with you, your powder is very fresh, i'm very happy with the quality, we are going to build a stable coopertion with you.

—— Sl Woolford

Very quick delivery. thank you bro,and ,my clients very satisfy, quality even good than other supplier, amazing ! I will back to u soon

—— Michael Edw

Your products perfect, i'm starting to make the more orders and pls give me your best price again

—— Trujillo Tucson

Top Quality Powder Nsi-189 CAS 1270138-40-3 for Memory Enhancement and Depressive Disorder Treatment

Top Quality Powder Nsi-189 CAS 1270138-40-3 for Memory Enhancement and Depressive Disorder Treatment
Top Quality Powder Nsi-189 CAS 1270138-40-3 for Memory Enhancement and Depressive Disorder Treatment Top Quality Powder Nsi-189 CAS 1270138-40-3 for Memory Enhancement and Depressive Disorder Treatment Top Quality Powder Nsi-189 CAS 1270138-40-3 for Memory Enhancement and Depressive Disorder Treatment

Large Image :  Top Quality Powder Nsi-189 CAS 1270138-40-3 for Memory Enhancement and Depressive Disorder Treatment Get Best Price

Product Details:
Place of Origin: China
Brand Name: Doublewin
Certification: USP
Model Number: CAS NO. 1270138-40-3
Payment & Shipping Terms:
Minimum Order Quantity: 10grams
Packaging Details: Strict packaging
Delivery Time: Within 24 hours
Payment Terms: T/T, Western Union, MoneyGram,Bitcoin
Supply Ability: 1000kg/month
Detailed Product Description
Product Name: NSI-189 CAS: 1270138-40-3
MF: C22H30N4O MW: 366.4998
Purity: 99% Appearance: White Crystal Powder
Origin: China WhatsApp: +86 17683962426
High Light:

GMP Anti Estrogen Steroids

,

Medical Grade Raw Steroids Powder

,

EP5 Raw Steroids Powder

Product Name: NSI-189

 

Product Details:

 

 

Product Name

 

NSI-189

 

Alias

 

NSI-189 Phosphate

 

CAS

 

1270138-40-3

 

MF

 

C22H30N4O

 

MW

 

366.4998

 

Purity

 

99% Min

 

MP

 

83ºC-86ºC

 

Grade

 

Pharmaceutical Grade

 

Appearance

 

White Powder

 

 

Describtion :

 

NSI-189 is a benzylphiperizine-aminiopyridine, nootropic and neurogenic research chemical created by Neuralstem, Inc. that was derived from pyrazine and nicotinamide. Studies have shown that it stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro . In healthy adult mice, NSI-189 has been shown to increase the hippocampal volume by 20% and reverse behavioral symptoms in mouse depression models, meaning at the source it could address depression . The hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory. The chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to be contributory in conditions such as post-traumatic stress disorder (PTSD), Alzheimer's disease, and major depressive disorder (MDD).

NSI-189 is an experimental, novel potential antidepressant that is under investigation byNeuralstem, Inc. for the treatment for major depressive disorder (MDD), as well as for cognitive impairment and neurodegeneration. Research into NSI-189 has been funded by theDefense Advanced Research Projects Agency (DARPA) and the National Institutes of Health(NIH).The mechanism of action of NSI-189 appears to be activation of neurogenesis in thehippocampus and possible enlargement of this structure, but how the drug mediates these effects is unknown and binding studies have so far failed to identify any certain molecular targets for the drug. As stated by Neuralstem, NSI-189 is a "new chemical entity with [a] novel mechanism of action, molecular target yet unknown, but not mediated by SSRI or SNRIor by BDNF release or via any known GPCRs, kinases, or channels." The drug was discovered via high-throughput screening of a library of 10,269 compounds for neurogenic effects in vitro.

NSI-189 is neurogenic and nootropic research agent that was developed from nicotinamide and pyrazine. Randomized controlled trials have shown that it stimulates neurogenesis or neuronal cell production in the brain. In animal studies, it has also been shown to increase the volume of hippocampus by 20% thereby reversing behavioral symptoms of depression. Such studies have shown that it may be an effective treatment for depression. It is also thought to be a promising treatment for other condition including post-traumatic stress disorder (PTSD), Alzheimer's disease and age-related cognitive problems. NSI-189 has been proved that is thought to potentially promote increased neuronal production whilst treat depression is NSI-189. This article discusses NSI-189 and how this novel nootropic agent can revolutionize the treatment for depression, and possibly other neurodegenerative disorders. Current treatments for major depressive disorder (MDD) mostly include the use of oral medications to modulate critical neurotransmitters in the brain. Selective serotonin reuptake inhibitors (SSRIs) are believed to be the most commonly and widely prescribed treatment for depression. Most recent research however reveals that there is a new theory regarding the cause of major depressive disorder. This theory implicates that brain physiology also influences depression rather than brain chemistry problems alone. Researchers have discovered that the disease leads to decreased hippocampal volume. Note that a healthy hippocampus is an excellent source of neural stem cells which lead to the production of neurons. Neurons on the other hand are critical for creating essential new connections in the brain. Through the production of new neurons in the hippocampal area, depression can be treated.

 

 

 

 

COA:

 


Product name


NSI-189
CAS No.
1270138-40-3
Outer Packing  
Production date
Dec. 15. 2016.
Shelf life
Dec. 14th. 2019
Standard adopted

in-house standard
Items of analysis Specification Results


Appearance


Off-white powder


Confrom


Identification


IR and HPLC spectrum shall conform to the standard sample


conform


Melting Point


83ºC~86ºC


84.3ºC~85.6ºC


Loss on Drying


Less than 0.5%


0.29%


Purity(On Dried Base,HPLC)


NLT 99.5 %


99.62%


Total Impurity


Less than 0.5%


0.33%


Residue On Ignition


≤0.2%


0.16%


Heavy metal


≤20ppm


conform
Conclusion Qualified

 

 

Function:

 

1) Enhance cognition and memory formation.
2) Anxiolytic properties.
3) Anti-depressive effect .
4) Treatment of Alzheimer's and Parkinson's disease.
5) Increase coordination.
6) Improves mood.
7) Help fight fatigue.
8) Prevent oxidation within the brain.
9) Treat alcohol related brain damage.

 

 

Benefits:

 

NSI-189 significantly improved behavioral responses that are associated with depression. In humans it may counter hippocampal atrophy which is seen in disorders such as MDD, reversing their symptoms. A phase 1B randomized, double-blind, placebo-controlled, multiple-dose escalation study conducted over a 28 day period showed behavioral efficacy in 24 patients who were orally administered NSI-189. The efficacy measurements showed a clinically meaningful reduction in cognitive and depressive symptoms across all measures, and appeared to persist over time during follow up for the efficacy assessments which included the Clinical Global Impression - Improvement (CGI-I), Montgomery-Aserb Depression Rating Scale (MADRS), Cognitive and Physical Functioning Questionnaire (CPFQ, and the Symptoms of Depression Questionnaire (SDQ).

 

 

 

 

Email:doublewin-eunice@nandrolonesteroid.com

WhatsApp:+86 17683962426

Skype:eunice1998

 

Contact Me!

 

 

 

Top Quality Powder Nsi-189 CAS 1270138-40-3 for Memory Enhancement and Depressive Disorder Treatment 0

Top Quality Powder Nsi-189 CAS 1270138-40-3 for Memory Enhancement and Depressive Disorder Treatment 1

 

 

We also Supply    
     
Oral Products Oxandrolone (Anavar) Stanozolol (Winstrol)
Oxymetholone (Anadrol) Dianabol(Methandrostenolone)
Testosterone Test Base 17-methyltestostero(methyl testos terone)
Test Enanthate 17α-Methyl-Testos terone
Test Acetate Oral turinabol(4-Chlorodehydromethyltestosterone)
Test Propionate Turinabol(Chloroterone Acetate,Clostebol Acetate)
(Test Phenylpropionate)
Test Isocaproate Hexadrone
Test Decanoate Mesterolone(Proviron)
Test Undecanoate Test Cypionate
1-Testosterone Test Sustanon 250
1-Testosterone Cypionate  
Nandrolone Nandrolone Nandrolone Undecanoate
Nandrolone Propionate Nandrolone Cypiontate
Nandrolone Decanoate(DECA) Stanolone (DHT)
Nandrolone Phenypropionate  
Mestanolone  
Boldenone Boldenone base  
Boldenone Propionate  
Boldenone Undecylenate(Equipoise)  
Boldenone cypiontate  
Boldenone Acetate  
Trenbolone Trenbolone base  
Trenbolone acetate (Finaplix)  
Trenbolone enanthate (Parabolan)  
Trenbolone hexahydrobenzyl Carbonate  
Ti bolone  
Methylstenbolone  
Methenolone Drostanolone Propionate (Masteron p)  
Methenolone Enanthate Methenolone Acetate
DH EA DHEA(Dehydroepiandrosterone) Epiandrosterone
1-DHEA Epiandrosterone Acetate
4-DHEA  
7-Keto-DH EA  
   
Others Methyl dienedione 2, 4-Dinitrophenol
Trendione/Trenavar Dustasteride
6-OXO Des onide
11-OXO Tria mcinolone
Epistane/Methyl Epitiostanol Finasteride
Androstatrienedione Cytomel, T3
  L-Thyroxine, T4
  Rimonabant
  L-Carnitine
Sex Enhancer Flibanserin Acetildenafil (Hongdenafil)
Cia lis (Tadalafil) Yohimbine Hcl
Via gra (Silde nafil) Vardenafil (Le vitra)  
  Maca Extract
Pain Killer Benzocaine / Benzocaine hcl Tetracaine / Tetracaine HCL
Procaine / Procaine Hcl Bupivacaine/ Bupivacaine HCL
Lidocaine HCL Articaine / Articaine hcl
Anti-Estrogen Tamoxifen Citrate (Nolvadex) Anastrozole (Arimidex)
Clomiphene citrate (Clomid) Letrazole(Femara / For mestane)
Exe mestane(Aromasin)  
Pharmaceuticals Phe nacetin Raloxifene HCL
  Theophylline
Dexamethasone Sodium Phosphate Fura zabol THP
Paracetamol Atorvastatin Calcium
Pregabalin Lorcaserin
  Carbergoline
Safe Organic Solvents Gamma-Butyrolactones(GBLsolvents ) Benzyl Alcohol(BA)
1,4-Butanediol(BDO) Benzyl benzoate(BB)
Ethyl Oleate(EO) Guaiacol
Grape Seed Oil(GSO) Poly Ethylene Glycol(PEG)
  Polysorbate 80
H G H&Peptides HGH 176-191 2mg/vial Ipamorelin 2mg/vial
MGF PEG MGF Hexarelin 2mg/vial
CJC-1295 / with DAC Sermorelin 2mg/vial
PT-141 10mg/vial Selank 5mg/vial
MT-1 MT-2 10mg/vial Follistatin 344
GHRP-2 5mg/vial & 10mg/vial Follistatin 315
GHRP-6 5mg/vial & 10mg/vial Eptifibatide
SARMs Aicar MK-2866/Ostarine/Enobosarm
Andarine / S4 RAD-140
Andarine / GTX-007 SR9011
GW-501516(cardarine) SR9009
LGD-4033 Sunifiram
MK-677/Ibutamoren/Nutrobal YK11



Order step:

1: After our quation ,you will choose to accept or not.

2: If you decide to have a try, choose a payment method to pay for the order.

3: We will sent the package out in 24hours after we received the payment ,then will sent the tracking number with packaging detail to you via mai.

4: We will help track the package until you receive it successful,if accident happen ,we will see the reason to decide re-sent for free or half-price re-sent.


Our Competitive Advantages:
1. Rich experience: we specialize in this field for many years, our steroids have been exported almost over the world. Such as USA, Canada, UK, Brazil, Germany, Russia, Australia, Greece, Poland, Bulgaria, Rumania, Netherlands, Sweden, Ukraine, Latvia, Lithuania, Ireland, Austria, Iran, Turkey, Mexico, Thailand, India, Malaysia, Singapore, other Middle East countries, European countries, American countries and more Areas.
2. Great quality: High purity and Favorable price. Good quality is the first base of our success. All of our products enjoys high purity. Thus, it can make sure your demand. Welcome order the samples, MOQ just 10 grams.
3. Safe and fast delivery: Lots of different discreet safe packing methods, experience in choosing express, 4~7 days to arrive, successful rate 99%.
4. Experiential order and cooperation: Besides raw powders, we offer hormone solution and Recipes. We can teach you or discuss how to make hormone solution on the site. Any discussion and question is welcome!

Packaging & Service:
1. Mass stock, to make sure delivery promptly every day when the payment is done.
2. Having been engaged in this field for years, we have sophisticated and professional logistics department, which can guarantee safe and speedy delivery.
3. Well-trained and disciplined packing team which is professional enough to provide you a safe package. It also avoid a lot of emergency happen during the delivery so that high customs pass is guaranteed. Unique ways to ship 10grams to 20 kilograms powders(or 100ml to 30 Liter liquids) at one time to your destination.
4. Packing pictures and tacking number are provided within 24 hours as soon as receiving the payment. Updated tracking code will be provided every other day just for you can hold a palm of your package.
5. Perfect after-sale service: Any questions or problems happened after receiving the product.
Please feel free to contact us. 24/7 online to solve your various problems!

 

 

Contact Details
Doublewin Biological Technology Co., Ltd.

Contact Person: Eunice

Tel: +8617683962426

Send your inquiry directly to us