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Factory Price Pharmaceutical Intermediate Raw Powder NSI-189 Phosphate CAS 1270138-41-4 For Antidepressant

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Factory Price Pharmaceutical Intermediate Raw Powder NSI-189 Phosphate CAS 1270138-41-4 For Antidepressant

Factory Price Pharmaceutical Intermediate Raw Powder NSI-189 Phosphate CAS 1270138-41-4 For Antidepressant
Factory Price Pharmaceutical Intermediate Raw Powder NSI-189 Phosphate CAS 1270138-41-4 For Antidepressant Factory Price Pharmaceutical Intermediate Raw Powder NSI-189 Phosphate CAS 1270138-41-4 For Antidepressant Factory Price Pharmaceutical Intermediate Raw Powder NSI-189 Phosphate CAS 1270138-41-4 For Antidepressant

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Product Details:
Place of Origin: China
Brand Name: Doublewin
Certification: USP
Model Number: CAS NO. 1270138-40-3
Payment & Shipping Terms:
Minimum Order Quantity: 10grams
Packaging Details: Strict packaging
Delivery Time: Within 24 hours
Payment Terms: T/T, Western Union, MoneyGram,Bitcoin
Supply Ability: 1000kg/month
Detailed Product Description
Product Name: NSI-189 CAS: 1270138-40-3
MF: C22H30N4O MW: 366.4998
Purity: 99% Appearance: White Crystal Powder
Origin: China WhatsApp: +86 17683962426
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Factory Price Pharmaceutical Intermediate Raw Material Powder NSI-189 CAS 1270138-40-3 For Antidepressant

 

 

NSI-189

 

 

CAS:1270138-40-3

MF:C22H30N4O

MW: 366.4998

EINECS:-0

Synonyms:NSI-189;[2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone;[2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone NSI189;NSI-189 [2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone;NSI-189, >=98%;(4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl];(4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl],NSI-189

 

 

Background

NSI-189 is a benzylphiperizine-aminiopyridine, nootropic and neurogenic research chemical created by Neuralstem, Inc. that was derived from pyrazine and nicotinamide. Studies have shown that it stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro .

 

In healthy adult mice, NSI-189 has been shown to increase the hippocampal volume by 20% and reverse behavioral symptoms in mouse depression models, meaning at the source it could address depression . The hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory.

 

The chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to be contributory in conditions such as post-traumatic stress disorder (PTSD), Alzheimer's disease, and major depressive disorder (MDD).

 


Method of Action

Although it has been demonstrated in rats and chimps, the suggestion that having too small of a hippocampus causes depression and other diseases in humans is still technically just a theory. NSI-189 increases hippocampal volume in adult mice by 20%, a region of the brain that is one of the first to suffer damage resulting in memory loss, disorientation, encephalitis, and hypoxia from disease's such as Alzheimer's .

 

Benefits

Tests have shown that NSI-189 significantly improved behavioral responses that are associated with depression . In humans it may counter hippocampal atrophy which is seen in disorders such as MDD, reversing their symptoms. A phase 1B randomized, double-blind, placebo-controlled, multiple-dose escalation study conducted over a 28 day period showed behavioral efficacy in 24 patients who were orally administered NSI-189 .

 

The efficacy measurements showed a clinically meaningful reduction in cognitive and depressive symptoms across all measures, and appeared to persist over time during follow up for the efficacy assessments which included the Clinical Global Impression - Improvement (CGI-I), Montgomery-Aserb Depression Rating Scale (MADRS), Cognitive and Physical Functioning Questionnaire (CPFQ, and the Symptoms of Depression Questionnaire (SDQ) .

 

 

How NSI-189 works


This drug was developed to address three important aspects of depression including hippocampal volume, neurogenesis and neurotransmission. NSI-189 increases the volume within the hippocampus. In so doing, hippocampal volume and healthy brain cell density is increased thereby improving mod and cognitive performance. Aside from increasing hippocampal volume, the drug also improves neuronal cell functionality. It works it promoting healthy neuronal cell growth whilst repair damaged areas in the brain.


Dosage and Suggestion


Studies conducted to evaluate effects of NSI-189 revealed that 40 to 80 mg daily is effective in treating depression and cognitive symptoms amongst healthy patients. In these trials, there are no serious adverse events recorded. Generally, NSI-189 is well tolerated and safe for human use.

 

 

 

Factory Price Pharmaceutical Intermediate Raw Powder NSI-189 Phosphate CAS 1270138-41-4 For Antidepressant 0

 

 

 

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Skype:eunice1998

 

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1: After our quation ,you will choose to accept or not.

2: If you decide to have a try, choose a payment method to pay for the order.

3: We will sent the package out in 24hours after we received the payment ,then will sent the tracking number with packaging detail to you via mai.

4: We will help track the package until you receive it successful,if accident happen ,we will see the reason to decide re-sent for free or half-price re-sent.


Our Competitive Advantages:
1. Rich experience: we specialize in this field for many years, our steroids have been exported almost over the world. Such as USA, Canada, UK, Brazil, Germany, Russia, Australia, Greece, Poland, Bulgaria, Rumania, Netherlands, Sweden, Ukraine, Latvia, Lithuania, Ireland, Austria, Iran, Turkey, Mexico, Thailand, India, Malaysia, Singapore, other Middle East countries, European countries, American countries and more Areas.
2. Great quality: High purity and Favorable price. Good quality is the first base of our success. All of our products enjoys high purity. Thus, it can make sure your demand. Welcome order the samples, MOQ just 10 grams.
3. Safe and fast delivery: Lots of different discreet safe packing methods, experience in choosing express, 4~7 days to arrive, successful rate 99%.
4. Experiential order and cooperation: Besides raw powders, we offer hormone solution and Recipes. We can teach you or discuss how to make hormone solution on the site. Any discussion and question is welcome!

Packaging & Service:
1. Mass stock, to make sure delivery promptly every day when the payment is done.
2. Having been engaged in this field for years, we have sophisticated and professional logistics department, which can guarantee safe and speedy delivery.
3. Well-trained and disciplined packing team which is professional enough to provide you a safe package. It also avoid a lot of emergency happen during the delivery so that high customs pass is guaranteed. Unique ways to ship 10grams to 20 kilograms powders(or 100ml to 30 Liter liquids) at one time to your destination.
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Contact Details
Doublewin Biological Technology Co., Ltd.

Contact Person: Eunice

Tel: +8617683962426

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